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This note explains the following topics: Concept of allergy and anaphylaxis, Hypersensitivity, Immediate versus delayed hypersensitivity, Gell and coombs classification of hypersensitive reactions, Type I hypersensitivity, Degranulation process and its mechanism, Mediators of type I hypersensitivity, Clinical manifestations of type I hypersensitivity, Regulation of type I hypersensitivity, Detection of type I hypersensitivity, Therapy or prec